The 'atypicality' of antipsychotics: a concept re-examined and re-defined

  title={The 'atypicality' of antipsychotics: a concept re-examined and re-defined},
  author={Gerhard Gr{\"u}nder and Hanns Hippius and Arvid Carlsson},
  journal={Nature Reviews Drug Discovery},
Recent clinical trials have raised questions over the perceived advantages of second-generation 'atypical' antipsychotics over those from the first generation. An atypical antipsychotic in its original sense is one that lacks extrapyramidal side effects. However, the addition of other clinical features to the original concept of atypicality, such as efficacy against negative and cognitive symptoms, seems to have become a feature of searches for novel antipsychotics in the past two decades… CONTINUE READING

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