The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation

@article{Nilsberth2001TheA,
  title={The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation},
  author={Camilla Nilsberth and Anita Westlind-Danielsson and Christopher B. Eckman and Margaret A M Condron and Karin Axelman and Charlotte Forsell and Charlotte Stenh and Johan Luthman and David B Teplow and Steven G. Younkin and Jan Erik N{\"a}slund and Lars Lannfelt},
  journal={Nature Neuroscience},
  year={2001},
  volume={4},
  pages={887-893}
}
Several pathogenic Alzheimer's disease (AD) mutations have been described, all of which cause increased amyloid β-protein (Aβ) levels. Here we present studies of a pathogenic amyloid precursor protein (APP) mutation, located within the Aβ sequence at codon 693 (E693G), that causes AD in a Swedish family. Carriers of this 'Arctic' mutation showed decreased Aβ42 and Aβ40 levels in plasma. Additionally, low levels of Aβ42 were detected in conditioned media from cells transfected with APPE693G… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

the solution to an Alzheimer’s disease conundrum? Trends Neurosci

  • W. L. Klein, G. A. Krafft, Finch, C. E. Targeting small Aβ oligomers
  • 24, 219–224
  • 2001
1 Excerpt

Intraneuronal Aβ42 accumulation in human brain

  • Gouras, K G.
  • Am. J. Pathol. 156,
  • 2000
1 Excerpt

implications for pathogenesis and therapy

  • Conway, K. A. et al. Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations li disease
  • Proc. Natl. Acad. Sci. USA 97, 571–576
  • 2000
1 Excerpt

A new βPP mutation related to hereditary cerebral haemorrhage

  • F Tagliavini
  • Alz. Report 2,
  • 1999
1 Excerpt

Amyloid β-protein fibrillogenesis—structure and biological activity of protofibrillar intermediates

  • Walsh, M D.
  • J. Biol. Chem
  • 1999
1 Excerpt

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