The "second gas effect" is not a valid concept.

@article{XG1999TheG,
  title={The "second gas effect" is not a valid concept.},
  author={Sun X-G and Felice Su and You Qi Shi and Chrisitane Lee},
  journal={Anesthesia and analgesia},
  year={1999},
  volume={88 1},
  pages={
          188-92
        }
}
UNLABELLED To determine whether the "second gas effect" is valid, we determined the pharmacokinetics of 0.2% enflurane with or without 80% N2) (n = 7 each) under controlled constant volume ventilation in 14 young healthy male patients before their operations. The alveolar (end-tidal) concentration (FA) and inspired concentration (FI) at the mouthpiece and the arterial blood concentration of enflurane were measured, and the ratio of FA to FI was calculated. The FA/FI of enflurane increased… CONTINUE READING
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