The "occlusis" model of cell fate restriction.

  title={The "occlusis" model of cell fate restriction.},
  author={Bruce T. Lahn},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={33 1},
A simple model, termed "occlusis", is presented here to account for both cell fate restriction during somatic development and reestablishment of pluripotency during reproduction. The model makes three assertions: (1) A gene's transcriptional potential can assume one of two states: the "competent" state, wherein the gene is responsive to, and can be… CONTINUE READING