The "kynurenate test", a biochemical assay for putative cognition enhancers.

@article{Pittaluga1997TheT,
  title={The "kynurenate test", a biochemical assay for putative cognition enhancers.},
  author={Anna Pittaluga and Diego Vaccari and Maurizio Raiteri},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1997},
  volume={283 1},
  pages={82-90}
}
Some putative cognition enhancers (oxiracetam, aniracetam and D-cycloserine) were previously shown to prevent the kynurenic acid antagonism of the N-methyl-D-aspartate (NMDA)-evoked norepinephrine (NE) release in rat hippocampal slices. This functional in vitro assay was further characterized in the present work. D-Serine, a glutamate coagonist at the NMDA receptor glycine site, concentration-dependently (EC50 approximately 0.1 microM) prevented the kynurenate (100 microM) block of the NMDA… CONTINUE READING

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