The "in vitro" effects of lithium on the immune system.

  title={The "in vitro" effects of lithium on the immune system.},
  author={Rhoda Wilson and W. D. Fraser and J H Mckillop and Jennifer Bengston Smith and Denis St J O'Reilly and J. Arthur Thomson},
  volume={4 1-2},
This study has examined the "in vitro" effects of Lithium Carbonate on the immune system at low (10(-3), 10(-2)mM) and therapeutic (0.5-1.5 mM) concentrations. Lithium, in the presence of a range of mitogens, was found to increase the incorporation of 3H-thymidine into peripheral blood mononuclear (PBM) cells. At concentrations greater than 1 mM IL2 production was also enhanced. Lithium was also found to increase IgG and IgM production--an estimate of B cell function, the effects being greatest… CONTINUE READING

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