The "generic" effect of food on tacrolimus pharmacokinetics.

@article{Steiner2011TheE,
  title={The "generic" effect of food on tacrolimus pharmacokinetics.},
  author={R. W. Prasaad Steiner and Ashley A. Feist},
  journal={Clinical transplantation},
  year={2011},
  volume={25 2},
  pages={334-5}
}
A recent commentary entitled ‘‘Can generics be trusted?’’ questioned a standard of bioequivalence that would allow a 20% increase or decrease in the blood levels produced by ‘‘equivalent’’ doses of generic tacrolimus (TAC) and branded product (Prograf) (1). Understandable concern was voiced over possible increased rejection risks and need for further study of possible dangers of generic TAC (1). However, it is not as well recognized that concomitant food ingestion may reduce exposure of both… CONTINUE READING