The "a disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functions.

@article{Reiss2009TheD,
  title={The "a disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functions.},
  author={Karina Reiss and Paul Saftig},
  journal={Seminars in cell & developmental biology},
  year={2009},
  volume={20 2},
  pages={126-37}
}
There is an exciting increase of evidence that members of the disintegrin and metalloprotease (ADAM) family critically regulate cell adhesion, migration, development and signalling. ADAMs are involved in "ectodomain shedding" of various cell surface proteins such as growth factors, receptors and their ligands, cytokines, and cell adhesion molecules. The regulation of these proteases is complex and still poorly understood. Studies in ADAM knockout mice revealed their partially redundant roles in… CONTINUE READING
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