The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice

  title={The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice},
  author={K. Hayakawa and R. R. Hardy and D. Parks and L. Herzenberg},
  journal={The Journal of Experimental Medicine},
  pages={202 - 218}
  • K. Hayakawa, R. R. Hardy, +1 author L. Herzenberg
  • Published 1983
  • Biology, Medicine
  • The Journal of Experimental Medicine
  • A small subpopulation of normal murine splenic B cells carrying all of the classic B cells markers (IgM, IgD, Ia, and ThB) also carries Ly-1, one of the major T cell surface molecules. This "Ly-1 B" subpopulation (identified and characterized by multiparameter FACS analyses) consists of relatively large, high IgM/low-IgD/low-Ly-1 lymphocytes that represent approximately 2% of the spleen cells in normal animals and, generally, 5-10% of spleen cells in NZB mice. Ly-1 B are clearly detectable in… CONTINUE READING
    776 Citations
    Unusual phenotype of B cells in the thymus of normal mice
    • 112
    • PDF
    Progenitors for Ly-1 B cells are distinct from progenitors for other B cells
    • 580
    • PDF
    The Ly-1 B cell lineage.
    • 210
    • PDF
    Ly-1 as a differentiation antigen on normal and neoplastic B cells.
    • 23
    Generation of Ly‐1 B Cells from Developmentally Distinct Precursors
    • 30
    Coexpression of Lyb-2 and Mac-1 by murine lymphomas and subpopulations of normal spleen and bone marrow cells.
    • K. Holmes, H. Morse
    • Biology, Medicine
    • Current topics in microbiology and immunology
    • 1984
    • 7


    Expression of Lyt-1 by a subset of B lymphocytes.
    • 197
    Expression of Lyt-1 antigen on certain murine B cell lymphomas
    • 112
    • PDF
    Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse
    • 241
    • PDF
    Functional subclasses of T lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity.
    • 659
    • PDF