The "Gab" in signal transduction.

@article{Gu2003TheI,
  title={The "Gab" in signal transduction.},
  author={Haihua Gu and Benjamin G Neel},
  journal={Trends in cell biology},
  year={2003},
  volume={13 3},
  pages={122-30}
}
Tyrosine phosphorylation plays an important role in controlling cellular growth, differentiation and function. Abnormal regulation of tyrosine phosphorylation can result in human diseases such as cancer. A major challenge of signal transduction research is to determine how the initial activation of protein-tyrosine kinases (PTKs) by extracellular stimuli triggers multiple downstream signaling cascades, which ultimately elicit diverse cellular responses. Recent studies reveal that members of the… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS