The "Gab" in signal transduction.

  title={The "Gab" in signal transduction.},
  author={Haihua Gu and Benjamin G Neel},
  journal={Trends in cell biology},
  volume={13 3},
Tyrosine phosphorylation plays an important role in controlling cellular growth, differentiation and function. Abnormal regulation of tyrosine phosphorylation can result in human diseases such as cancer. A major challenge of signal transduction research is to determine how the initial activation of protein-tyrosine kinases (PTKs) by extracellular stimuli triggers multiple downstream signaling cascades, which ultimately elicit diverse cellular responses. Recent studies reveal that members of the… CONTINUE READING
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