The "Epigenetic Code Replication Machinery", ECREM: a promising drugable target of the epigenetic cell memory.

@article{Bronner2007TheC,
  title={The "Epigenetic Code Replication Machinery", ECREM: a promising drugable target of the epigenetic cell memory.},
  author={Christian Bronner and Thierry Chataigneau and Val{\'e}rie B. Schini-Kerth and Yves Landry},
  journal={Current medicinal chemistry},
  year={2007},
  volume={14 25},
  pages={
          2629-41
        }
}
Discrete chemical modifications of the chromatin (DNA and primarily histones) can regulate gene expression or repression and can be transmitted to the descent (cells or organisms) thanks to an epigenetic memory. These modifications involve histone post-translational modifications, DNA methylation at CpG islands and small nuclear RNAs processes. They play fundamental roles in cell proliferation and differentiation. These two processes are crucial in particular during embryonic development, X… CONTINUE READING

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