The "Achilles' Heel" of Cancer and Its Implications for the Development of Novel Immunotherapeutic Strategies.

@article{Joshi2018TheH,
  title={The "Achilles' Heel" of Cancer and Its Implications for the Development of Novel Immunotherapeutic Strategies.},
  author={Kroopa Joshi and Benjamin M. Chain and Karl S. Peggs and Sergio A Quezada},
  journal={Cold Spring Harbor perspectives in medicine},
  year={2018},
  volume={8 1}
}
Over the last century, scientists have embraced the idea of mobilizing antitumor immune responses in patients with cancer. In the last decade, we have seen the rebirth of cancer immunotherapy and its validation in a series of high profile clinical trials following the discovery of several immune-regulatory receptors. Recent studies point toward the tumor mutational load and resulting neoantigen burden as being crucial to tumor cell recognition by the immune system, highlighting a potentially… CONTINUE READING
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