Thapsigargin induces biphasic fragmentation of mitochondria through calcium-mediated mitochondrial fission and apoptosis.

@article{Hom2007ThapsigarginIB,
  title={Thapsigargin induces biphasic fragmentation of mitochondria through calcium-mediated mitochondrial fission and apoptosis.},
  author={Jennifer R Hom and Jennifer S. Gewandter and Limor Michael and Shey-Shing Sheu and Yisang Yoon},
  journal={Journal of cellular physiology},
  year={2007},
  volume={212 2},
  pages={498-508}
}
Mitochondrial fission and fusion are the main components mediating the dynamic change of mitochondrial morphology observed in living cells. While many protein factors directly participating in mitochondrial dynamics have been identified, upstream signals that regulate mitochondrial morphology are not well understood. In this study, we tested the role of intracellular Ca(2+) in regulating mitochondrial morphology. We found that treating cells with the ER Ca(2+)-ATPase inhibitor thapsigargin (TG… CONTINUE READING

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