Thapsigargin-induced apoptosis involves Cabin1-MEF2-mediated induction of Nur77.

  title={Thapsigargin-induced apoptosis involves Cabin1-MEF2-mediated induction of Nur77.},
  author={W Vincent Liu and Hong Duk Youn and Jun O Liu},
  journal={European journal of immunology},
  volume={31 6},
Thapsigargin (TG), which inhibits endoplasmic reticulum-dependent Ca(2 +)-ATPase and thereby increases cytosolic Ca(2 +), has been reported to cause apoptosis in T lymphocytes another cell types. In this study, we investigated the molecular mechanisms that are involved in the apoptosis induced by TG in T cell hybridomas. Exposure to TG results in rapid induction of the orphan steroid receptor, Nur77, accompanied by apoptosis of T cell hybridomas. The expression of Nur77 in response to TG… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…