Thapsigargin-induced apoptosis involves Cabin1-MEF2-mediated induction of Nur77.

@article{Liu2001ThapsigargininducedAI,
  title={Thapsigargin-induced apoptosis involves Cabin1-MEF2-mediated induction of Nur77.},
  author={W Vincent Liu and Hong Duk Youn and Jun O Liu},
  journal={European journal of immunology},
  year={2001},
  volume={31 6},
  pages={1757-64}
}
Thapsigargin (TG), which inhibits endoplasmic reticulum-dependent Ca(2 +)-ATPase and thereby increases cytosolic Ca(2 +), has been reported to cause apoptosis in T lymphocytes another cell types. In this study, we investigated the molecular mechanisms that are involved in the apoptosis induced by TG in T cell hybridomas. Exposure to TG results in rapid induction of the orphan steroid receptor, Nur77, accompanied by apoptosis of T cell hybridomas. The expression of Nur77 in response to TG… CONTINUE READING

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