Thapsigargin elevates and potentiates the ability of progesterone to increase intracellular free calcium in human sperm: possible role of perinuclear calcium.

@article{Blackmore1993ThapsigarginEA,
  title={Thapsigargin elevates and potentiates the ability of progesterone to increase intracellular free calcium in human sperm: possible role of perinuclear calcium.},
  author={Peter F. Blackmore},
  journal={Cell calcium},
  year={1993},
  volume={14 1},
  pages={53-60}
}
The effect of thapsigargin on intracellular free calcium ([Ca2+]i) was examined in swim up human sperm. Thapsigargin elevated [Ca2+]i in a dose dependent manner, with maximal effects observed with 10 microM. The increase in [Ca2+]i was relatively slow in taking 3-4 min to reach a maximal level. The increase in [Ca2+]i was inhibited when extracellular Ca2+ was chelated with EGTA, thus the source of Ca2+ for the increase was extracellular. The effect of thapsigargin to stimulate Ca2+ influx was… CONTINUE READING

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