Thalidomide stimulates splenic IgM antibody response and cytotoxic T lymphocyte activity and alters leukocyte subpopulation numbers in female B6C3F1 mice.

@article{Karrow2000ThalidomideSS,
  title={Thalidomide stimulates splenic IgM antibody response and cytotoxic T lymphocyte activity and alters leukocyte subpopulation numbers in female B6C3F1 mice.},
  author={Niel Alexander Karrow and J. Ann McCay and Ronnetta D. Brown and Deborah L Musgrove and Denise A Pettit and Albert E. Munson and Dori R. Germolec and Kimber L. White},
  journal={Toxicology and applied pharmacology},
  year={2000},
  volume={165 3},
  pages={237-44}
}
Thalidomide has been shown to have antiinflammatory and, more recently, immunomodulating properties, which are beneficial for the treatment of an ever-increasing list of immune related diseases. Although considerable knowledge regarding thalidomide s antiinflammatory properties has been acquired, relatively little is known about its immunomodulating properties in vivo. In this paper, a panel of immune assays was used to evaluate immunomodulation in female B6C3F1 mice treated intraperitoneally… CONTINUE READING