Thalidomide mimics uridine binding to an aromatic cage in cereblon.

  title={Thalidomide mimics uridine binding to an aromatic cage in cereblon.},
  author={Marcus D Hartmann and Iuliia Boichenko and Murray Coles and Fabio Zanini and Andrei N. Lupas and Birte Hernandez Alvarez},
  journal={Journal of structural biology},
  volume={188 3},
Thalidomide and its derivatives lenalidomide and pomalidomide are important anticancer agents but can cause severe birth defects via an interaction with the protein cereblon. The ligand-binding domain of cereblon is found, with a high degree of conservation, in both bacteria and eukaryotes. Using a bacterial model system, we reveal the structural determinants of cereblon substrate recognition, based on a series of high-resolution crystal structures. For the first time, we identify a cellular… CONTINUE READING
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