Thalidomide induces limb deformities by perturbing the Bmp/Dkkl/Wnt signaling pathway

@article{Knobloch2007ThalidomideIL,
  title={Thalidomide induces limb deformities by perturbing the Bmp/Dkkl/Wnt signaling pathway},
  author={J{\"u}rgen Knobloch and John D. Shaughnessy and Ulrich R{\"u}ther},
  journal={The FASEB Journal},
  year={2007},
  volume={21},
  pages={1410 - 1421}
}
Thalidomide, a sedative originally used to treat morning sickness and now used to treat leprosy and multiple myeloma, is also a teratogen that induces birth defects in humans such as limb truncations and microphthalmia. However, the teratogenic mechanism of action of this drug remains obscure. Thalidomide induces limb and eye defects in the chicken embryo at an EC50 of 50 μg/kg egg wt and apoptosis in primary human embryonic fibroblasts (HEFs) at an EC50 of 8.9 μM. Using these model systems, we… 

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