Thalidomide-induced antigen-specific immune stimulation in patients with human immunodeficiency virus type 1 and tuberculosis.

@article{Bekker2000ThalidomideinducedAI,
  title={Thalidomide-induced antigen-specific immune stimulation in patients with human immunodeficiency virus type 1 and tuberculosis.},
  author={Linda Gail Bekker and Patrick Haslett and Gary Maartens and L. J. C. Steyn and Gilla Kaplan},
  journal={The Journal of infectious diseases},
  year={2000},
  volume={181 3},
  pages={
          954-65
        }
}
Thalidomide, which inhibits monocyte tumor necrosis factor (TNF)-alpha production and costimulates T cells, was tested for immune modulation in patients with human immunodeficiency virus (HIV) infection and tuberculosis (TB) in a placebo-controlled study. Thalidomide therapy resulted in increased levels of plasma interleukin (IL)-2 receptor, soluble CD8, interferon-gamma, and IL-12, indicating immune stimulation. TNF-alpha levels were not reduced. Thalidomide treatment increased CD4+ and CD8+ T… CONTINUE READING

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