Thalidomide in total therapy 2 overcomes inferior prognosis of myeloma with low expression of the glucocorticoid receptor gene NR3C1.

@article{Heuck2012ThalidomideIT,
  title={Thalidomide in total therapy 2 overcomes inferior prognosis of myeloma with low expression of the glucocorticoid receptor gene NR3C1.},
  author={Christoph J. Heuck and Jackie D Szymonifka and Emily Hansen and John D. Shaughnessy and Saad Zafar Usmani and Frits van Rhee and Elias Anaissie and Bijay Nair and Sarah Waheed and Yazan Alsayed and Nathan M. Petty and Clyde Bailey and Joshua Epstein and Antje Hoering and John C Crowley and Bart Barlogie},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2012},
  volume={18 19},
  pages={5499-506}
}
PURPOSE Because dexamethasone remains a key component of myeloma therapy, we wished to examine the impact of baseline and relapse expression levels of the glucocorticoid receptor gene NR3C1 on survival outcomes in the context of treatment with or without thalidomide. EXPERIMENTAL DESIGN We investigated the clinical impact of gene expression profiling (GEP)-derived expression levels of NR3C1 in 351 patients with GEP data available at baseline and in 130 with data available at relapse, among… CONTINUE READING
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