Thalidomide and its sequelae

@article{Emanuel2012ThalidomideAI,
  title={Thalidomide and its sequelae},
  author={Michael Emanuel and Michael Rawlins and GordonW. Duff and Alasdair M. Breckenridge},
  journal={The Lancet},
  year={2012},
  volume={380},
  pages={781-783}
}
Dec 16, 1961, became one of the most important dates in the calendar of modern therapeutics when The Lancet published a letter from W G McBride, an Australian obstetrician, describing the tragedy of congenital abnormalities caused by use of thalidomide in pregnancy. Before this, Widukind Lenz, a German paediatrician, had written to Chemie Grünenthal, the manufacturer of thalidomide, expressing his concerns about the potential of the drug to cause multiple birth defects, and presented his data… Expand
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References

SHOWING 1-7 OF 7 REFERENCES
Thalidomide and Congenital Abnormalities
TLDR
It is observed that the incidence of multiple severe abnormalities in babies delivered of women who were given the drug thalidomide during pregnancy, as an anti-emetic or as a sedative, to be almost 20%. Expand
Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412.
TLDR
Six healthy young male volunteers at a contract research organization were enrolled in the first phase 1 clinical trial of TGN1412, a novel superagonist anti-CD28 monoclonal antibody that directly stimulates T cells, and experienced a systemic inflammatory response characterized by a rapid induction of proinflammatory cytokines. Expand
Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group.
TLDR
In patients with rheumatoid arthritis, treatment with rofecoxib, a selective inhibitor of cyclooxygenase-2, is associated with significantly fewer clinically important upper gastrointestinal events than treatment with naproxen, a nonselective inhibitor. Expand
A "pennurth of arsenic for rat poison": the Arsenic Act, 1851 and the prevention of secret poisoning.
In this country any chemist or druggist can furnish the means of self-destruction or murder for a few pence, and in too many instances have done so with the utmost indifference. The sale of a poisonExpand
New drugs and the Kefauver-Harris amendment.
  • J. Krantz
  • Medicine
  • The Journal of new drugs
  • 1966