author={Michael E. Franks and Gordon R. Macpherson and William Douglas Figg},
  journal={The Lancet},
Molecular Mechanisms and Determinants of Species Sensitivity in Thalidomide Teratogenesis
Chemical instability, potent general toxicity and absence of limb bud embryopathies make FTD an unsuitable stereoselective model for TD teratogenesis. Expand
Thalidomide and immunomodulatory drugs in the treatment of cancer
Thalidomide analogues, with higher immunomodulatory activity and different toxicity profile, have been developed and have already shown promising activity in multiple myeloma and are currently being evaluated in clinical studies. Expand
Deciphering the mystery of thalidomide teratogenicity
It is suggested that thalidomide downregulates fibroblast growth factor 8 expression and induces limb malformation by binding to wild‐type cereblon, inhibiting the function of the associated E3 ubiquitin ligase. Expand
Fluorothalidomide: a characterization of maternal and developmental toxicity in rabbits and mice.
The potential of fluorothalidomide (FTD), the closest structural analog of TD with stable, nonracemizing isomers, as a model compound for studying stereoselectivity in TD teratogenesis is evaluated. Expand
Protective effect of thalidomide against N‐methyl‐D‐aspartate‐induced retinal neurotoxicity
Thalidomide, an inhibitor of tumor necrosis factor‐α (TNF‐α) production, has been indicated to be useful for many inflammatory and oncogenic diseases. In the present study, we examined whetherExpand
A comprehensive review on anticancer mechanism of bazedoxifene.
This review mainly focused on the anticancer activity, cellular targets and anticancer mechanism of BZA which may help the further design and conduct of research and repositioning it for oncological clinic trials. Expand
A review of potential suggested drugs for coronavirus disease (COVID-19) treatment
Clinical investigations of potential therapeutic drugs used as COVID-19 therapy, finding that Emetine, Teicoplanin, and Nelfinavir have shown effectiveness in vitro, and the drugs currently under clinical trial. Expand
Advancing targeted protein degradation for cancer therapy
The molecular basis of targeted protein degradation is discussed, and a comprehensive account of the most promising degraders in development as cancer therapies to date is offered. Expand
Anatomical Considerations of Embryology and Development of the Musculoskeletal System: Basic Notions for Musculoskeletal Radiologists.
The embryology of the different components of the MSK system and their configuration as an organ-system is summarized, the clinical implications resulting from failures in the process of organogenesis are analyzed, and the first approach to diagnosis of skeletal abnormalities using prenatal ultrasound is described. Expand
Appetite problem in cancer patients: Pathophysiology, diagnosis, and treatment.
The pathophysiology of appetite problems in cancer patients is a complex process that involves many factors and several drugs that target those factors have been studied, however more phase 3 clinical trial studies are needed to confirm the findings from previous studies. Expand