Thalidomide: a review of approved and investigational uses.

@article{Matthews2003ThalidomideAR,
  title={Thalidomide: a review of approved and investigational uses.},
  author={S. J. Matthews and Christopher M McCoy},
  journal={Clinical therapeutics},
  year={2003},
  volume={25 2},
  pages={
          342-95
        }
}
BACKGROUND Thalidomide is best known as a major teratogen that caused birth defects in up to 12,000 children in the 1960s. More recently, this agent has been approved by the US Food and Drug Administration for the treatment of erythema nodosum leprosum (ENL) through a restricted-use program. Its immunomodulatory, anti-inflammatory, and antiangiogenic properties are currently under study in a number of clinical conditions. OBJECTIVE This article reviews the pharmacology of thalidomide; its… Expand

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