Thalassemia bone disease: a 19-year longitudinal analysis.

@article{Wong2014ThalassemiaBD,
  title={Thalassemia bone disease: a 19-year longitudinal analysis.},
  author={Phillip Wong and Peter James Fuller and MatthewT. Gillespie and Vicky Kartsogiannis and Peter George Kerr and James C. G. Doery and Elizebath Paul and Donald Keith Bowden and Boyd J.G. Strauss and Frances Milat},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2014},
  volume={29 11},
  pages={
          2468-73
        }
}
Thalassemia is an inherited disorder of alpha or beta globin chain synthesis leading to ineffective erythropoiesis requiring chronic transfusion therapy in its most severe form. This leads to iron overload, marrow expansion, and hormonal complications, which are implicated in bone deformity and loss of bone mineral density (BMD). In this 19-year retrospective longitudinal study, the relationships between BMD (determined by dual-energy X-ray absorptiometry) and risk factors for osteoporosis in… CONTINUE READING
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