Thalassemia and infertility

  title={Thalassemia and infertility},
  author={Maria Antonietta Castaldi and Luigi Cobellis},
  journal={Human Fertility},
  pages={90 - 96}
Abstract Beta-thalassemia (BTM) major is the most common haemoglobin disorder in the world, with high prevalence in people of Mediterranean, Arab or Asian origin. It has been estimated that about 1.5% of the global population (80–90 million people) are carriers of BTM. In patients with BTM, long-term transfusion therapy for the correction of anaemia leads to toxic iron overload, resulting in significant morbidity including liver damage, cardiac complications and endocrine dysfunction. The… 

Reproductive health issues in female patients with beta-thalassaemia major: a narrative literature review

Antenatal screening and accurate genetic prenatal examinations are effective measures to early diagnosis of thalassaemia and a detailed plan for management of pregnancies in BTM is important for favourable maternal and foetal outcome.

Pregnancy outcome in women with transfused beta-thalassemia in France

Pregnancy in transfused beta-thalassemia women is safe with rare obstetrical and fetal complications, and infant weight at birth remains smaller than that in the general population, despite delivery at full term.

Oocyte quality in women with thalassaemia major: insights from IVF cycles

Investigation and Management of Endocrinopathies in Thalassaemia Major

This chapter summarises the main presentations of endocrine disorder in thalassaemia, summarising their epidemiology, clinical presentation and pathophysiologic basis, and reviews screening, monitoring and treatment strategies.

Myocardial iron is strongly associated with reproductive function in beta-thalassemic women under chelation therapy

The present data shows that myocardial iron loading could be putative of prolonged and severe iron overload in the female genital tract, impairing fertility and reproductive function in patients affected with beta-thalassemia major under chelation therapy.

Consequences of β-Thalassemia or Sickle Cell Disease for Ovarian Follicle Number and Morphology in Girls Who Had Ovarian Tissue Cryopreserved

Follicles were detected in the ovarian cortex biopsies from all patients with BT and SCD and the follicle densities were within the 95% prediction interval of the reference group in all cases, suggesting OTC should be considered an option for young girls and adolescents with BT.

Fertility and pregnancy in Iranian thalassemia patients: An update on transfusion complications

This study aimed to assess the fertility status and stresses among thalassemia patients who desired to have children and the effectiveness of chelation regimens.

Investigating Some Of Blood Parameters In Women With β-Thalassemia

Blood tests for phytoplankton, blood groups and the level of ferritin in the body showed a significant decrease in all blood parameters, hemoglobin, blood corpuscular, corpuscular volume, mean corpuscular hemoglobin in corpuscular and mean corpuscules hemoglobin contraction, compared with control group.



Update on fertility in thalassaemia major.

The report of 358 successful pregnancies so far has provided strong evidence not only for the absence of any deleterious effect on the course of thalassaemia but also for the safety of the pregnancy in the thalASSaemic woman.

Current Perspectives of Fertility and Pregnancy in Thalassemia

In conclusion, pregnancy is feasible and safe in women with ß-thalassemia with normal resting cardiac performance and optimised iron overload in specialist centres under a multi disciplinary team.

Pregnancy and β-thalassemia: an Italian multicenter experience

Provided that a multidisciplinary team is available, pregnancy is possible, safe and usually has a favorable outcome in patients with thalassemia, and in women with hypog onadotropic hypogonadism, gonadal function is usually intact and fertility is usually retrievable.

The thalassemia syndromes and pregnancy, molecular basis, clinical aspects, prenatal diagnosis.

The obstetrics problems in B-Thalassemic tract pregnants as the various degree non iron dependent anemia and her complications in pregnancy and the risk of producing a homozygous child, are discussed.

Fertility in thalassemia: the Greek experience.

Pregnancy in beta-thalassemic patients has become a not unusual event and can be safe for both mothers and their babies with careful selection and appropriate care.

Fertility in female patients with thalassemia.

These collected data represent the largest number of pregnancies in thalassemic females reported so far and are clearly encouraging for the ultimate improvement of the quality of life in th alassemic patients.

The hypercoagulable state in thalassemia.

The presence of a higher than normal incidence of thromboembolic events, mainly in beta-TI, and the existence of prothrombotic hemostatic anomalies in the majority of the patients, even from a very young age, have led to the recognition of the existence a chronic hypercoagulable state in thalassemic patients.

Reproductive capacity in iron overloaded women with thalassemia major.

AMH emerges as an important biomarker for assessment of reproductive capacity in TM, demonstrating that fertility is preserved in the majority of those younger than 30 to 35 years, and can be useful in future studies aiming at improved chelation for fertility preservation.

Thalassaemia in pregnancy.

  • T. LeungT. Lao
  • Medicine
    Best practice & research. Clinical obstetrics & gynaecology
  • 2012

Fertility potential in thalassemia major women: current findings and future diagnostic tools

The relationship between liver iron concentration (LIC) and fertility status in 26 females and levels of LH/FSH and estradiol were low or undetectable in 48% and 35% of patients, respectively and did not correlate with age, presence of amenorrhea, and LIC.