Thalamocortical relay fidelity varies across subthalamic nucleus deep brain stimulation protocols in a data-driven computational model.

@article{Guo2008ThalamocorticalRF,
  title={Thalamocortical relay fidelity varies across subthalamic nucleus deep brain stimulation protocols in a data-driven computational model.},
  author={Yixin Guo and Jonathan E. Rubin and Cameron C. McIntyre and Jerrold L. Vitek and David Terman},
  journal={Journal of neurophysiology},
  year={2008},
  volume={99 3},
  pages={1477-92}
}
The therapeutic effectiveness of deep brain stimulation (DBS) of the subthalamic nucleus (STN) may arise through its effects on inhibitory basal ganglia outputs, including those from the internal segment of the globus pallidus (GPi). Changes in GPi activity will impact its thalamic targets, representing a possible pathway for STN-DBS to modulate basal ganglia-thalamocortical processing. To study the effect of STN-DBS on thalamic activity, we examined thalamocortical (TC) relay cell responses to… CONTINUE READING
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