Thalamic reductions in children with chromosome 22q11.2 deletion syndrome

@article{Bish2004ThalamicRI,
  title={Thalamic reductions in children with chromosome 22q11.2 deletion syndrome},
  author={Joel P. Bish and Vy Nguyen and Lijun Ding and Samantha Ferrante and Tony J. Simon},
  journal={NeuroReport},
  year={2004},
  volume={15},
  pages={1413-1415}
}
Children with chromosome 22q11.2 deletion syndrome (22q) suffer from physical and behavioral dysfunctions, including neuroanatomical anomalies, visuo-spatial processing deficits, and increased risk for psychopathology. Reduced total brain volume, parietal lobe volume, and cerebellar volumes, enlarged ventricles, and increased basal ganglia volumes have been reported. Since previous literature has related the pulvinar nucleus of the thalamus to visuo-spatial processing, we compared the thalamic… 
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Thalamic and thalamic reticular nucleus abnormalities in a patient with chromosome 22q11.2 deletion syndrome.
TLDR
Rare findings on ethyl cysteinate dimer single photon emission CT (SPECT) and MRI revealing abnormalities of the thalamus and thalamic reticular nucleus that may be associated with a psychiatric disorder are presented.
Hippocampal volume reduction in 22q11.2 deletion syndrome
Abnormal Development and Dysconnectivity of Distinct Thalamic Nuclei in Patients With 22q11.2 Deletion Syndrome Experiencing Auditory Hallucinations.
A multilevel analysis of cognitive dysfunction and psychopathology associated with chromosome 22q11.2 deletion syndrome in children
TLDR
Results presented support the hypothesis of posterior parietal dysfunction as a central determinant of characteristic visuospatial and numerical cognitive impairments and suggest that brain development anomalies, primarily tissue reductions in the posterior brain and changes to the corpus callosum, may affect parietal connectivity.
Mapping Subcortical Brain Alterations in 22q11.2 Deletion Syndrome: Effects of Deletion Size and Convergence With Idiopathic Neuropsychiatric Illness.
TLDR
In the largest neuroimaging study of 22q11DS to date, the authors found widespread alterations to subcortical brain structures, which were affected by deletion size and psychotic illness.
Cingulate gyral reductions are related to low executive functioning and psychotic symptoms in 22q11.2 deletion syndrome
Disrupted fornix integrity in children with chromosome 22q11.2 deletion syndrome
Domain specific attentional impairments in children with chromosome 22q11.2 deletion syndrome
Increased incidence and size of cavum septum pellucidum in children with chromosome 22q11.2 deletion syndrome
White matter microstructural abnormalities in girls with chromosome 22q11.2 deletion syndrome, Fragile X or Turner syndrome as evidenced by diffusion tensor imaging
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TLDR
Deletion at chromosome 22q11 is associated with brain abnormalities that are most likely neurodevelopmental and may partially explain the high prevalence of learning disability and psychiatric disorder in VCFS.
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TLDR
Results indicate that children with 22q 11.2 deletions display a specific neurocognitive phenotype, and suggest that this region of Chromosome 22q11 may harbor a gene or genes relevant to the etiology of nonverbal learning deficits.
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TLDR
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TLDR
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TLDR
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