Thalamic microinjection of nicotine reverses sevoflurane-induced loss of righting reflex in the rat.

Abstract

BACKGROUND Neuronal nicotinic acetylcholine receptors are both potently inhibited by anesthetics and densely expressed in the thalamus. Brain imaging shows that thalamic activity suppression accompanies anesthetic-induced unconsciousness. Therefore, anesthetic-induced unconsciousness may involve direct antagonism of thalamic nicotinic receptors. The authors… (More)

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@article{Alkire2007ThalamicMO, title={Thalamic microinjection of nicotine reverses sevoflurane-induced loss of righting reflex in the rat.}, author={Michael T. Alkire and J. R. McReynolds and Emily L Hahn and Akash N Trivedi}, journal={Anesthesiology}, year={2007}, volume={107 2}, pages={264-72} }