Thalamic microinfusion of antibody to a voltage-gated potassium channel restores consciousness during anesthesia.

@article{Alkire2009ThalamicMO,
  title={Thalamic microinfusion of antibody to a voltage-gated potassium channel restores consciousness during anesthesia.},
  author={Michael T. Alkire and Christopher D Asher and Amanda M Franciscus and Emily L Hahn},
  journal={Anesthesiology},
  year={2009},
  volume={110 4},
  pages={766-73}
}
BACKGROUND The Drosophila Shaker mutant fruit-fly, with its malfunctioning voltage-gated potassium channel, exhibits anesthetic requirements that are more than twice normal. Shaker mutants with an abnormal Kv1.2 channel also demonstrate significantly reduced sleep. Given the important role the thalamus plays in both sleep and arousal, the authors investigated whether localized central medial thalamic (CMT) microinfusion of an antibody designed to block the pore of the Kv1.2 channel might awaken… CONTINUE READING

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