Thalamic glutamate/glutamine in restless legs syndrome: increased and related to disturbed sleep.

@article{Allen2013ThalamicGI,
  title={Thalamic glutamate/glutamine in restless legs syndrome: increased and related to disturbed sleep.},
  author={Richard P. Allen and Peter B. Barker and A Horska and Christopher J. Earley},
  journal={Neurology},
  year={2013},
  volume={80 22},
  pages={2028-34}
}
OBJECTIVE To evaluate possible abnormal increase in thalamic glutamate/glutamine levels for restless legs syndrome (RLS) indicating increased glutamatergic activity producing arousal that at night disrupts and shortens sleep. METHODS (1)H MRS of the right thalamus was performed using a 1.5 T GE MRI scanner and the PROBE-P (PRESS) on 28 patients with RLS and 20 matched controls. The Glx signal (combination of mostly glutamate [Glu] and glutamine [Gln]) was assessed as a ratio to the total… CONTINUE READING
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