Thalamic cholinergic innervation and postural sensory integration function in Parkinson's disease.

@article{Mller2013ThalamicCI,
  title={Thalamic cholinergic innervation and postural sensory integration function in Parkinson's disease.},
  author={Martijn L. T. M. M{\"u}ller and Roger L Albin and Vikas Kotagal and Robert A. Koeppe and Peter J H Scott and Kirk A. Frey and Nicolaas I. Bohnen},
  journal={Brain : a journal of neurology},
  year={2013},
  volume={136 Pt 11},
  pages={3282-9}
}
The pathophysiology of postural instability in Parkinson's disease remains poorly understood. Normal postural function depends in part on the ability of the postural control system to integrate visual, proprioceptive, and vestibular sensory information. Degeneration of cholinergic neurons in the brainstem pedunculopontine nucleus complex and their thalamic efferent terminals has been implicated in postural control deficits in Parkinson's disease. Our aim was to investigate the relationship of… CONTINUE READING

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We studied 124 subjects with Parkinson 's disease ( 32 female/92 male ; 65.5 ± 7.4 years old ; 6.0 ± 4.2 years motor disease duration ; modified Hoehn and Yahr mean stage 2.4 ± 0.5 ) and 25 control subjects ( 10 female/15 male , 66.8 ± 10.1 years old ) .
We studied 124 subjects with Parkinson 's disease ( 32 female/92 male ; 65.5 ± 7.4 years old ; 6.0 ± 4.2 years motor disease duration ; modified Hoehn and Yahr mean stage 2.4 ± 0.5 ) and 25 control subjects ( 10 female/15 male , 66.8 ± 10.1 years old ) .
We studied 124 subjects with Parkinson 's disease ( 32 female/92 male ; 65.5 ± 7.4 years old ; 6.0 ± 4.2 years motor disease duration ; modified Hoehn and Yahr mean stage 2.4 ± 0.5 ) and 25 control subjects ( 10 female/15 male , 66.8 ± 10.1 years old ) .
Impaired integrity of pedunculopontine nucleus cholinergic neurons and their thalamic efferents play a role in postural control in patients with Parkinson 's disease , possibly by participating in integration of multimodal sensory input information .
Degeneration of cholinergic neurons in the brainstem pedunculopontine nucleus complex and their thalamic efferent terminals has been implicated in postural control deficits in Parkinson 's disease .
We conclude that postural sensory integration function of subjects with Parkinson 's disease is modulated by pedunculopontine nucleus - thalamic but not cortical cholinergic innervation .
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