Thalamic Contributions to Anterograde, Retrograde, and Implicit Memory: A Case Study

  title={Thalamic Contributions to Anterograde, Retrograde, and Implicit Memory: A Case Study},
  author={Benjamin M. Hampstead and Sandra P. Koffler},
  journal={The Clinical Neuropsychologist},
  pages={1232 - 1249}
Learning and memory deficits are typically associated with damage or dysfunction of medial temporal lobe structures; however, diencephalic lesions are another common cause of severe and persistent memory deficits. We focus specifically on the thalamus and review the pathological and neuropsychological characteristics of two common causes of such damage: Korsakoff's syndrome and stroke. We then present a patient who had sustained bilateral medial thalamic infarctions that affected the medial… 

Accelerated forgetting of contextual details due to focal medio-dorsal thalamic lesion

Assessment of thalamic stroke patients with consistent unilateral lesions focal to the left medio-dorsal nuclei for immediate and delayed memory performance on standard visual and verbal tests of anterograde memory, and over the long-term (>24 h) on an object-location associative memory task suggests a role for theMedio- dorsaluclei in recall and early consolidation memory processes.

Memory Profiles after Unilateral Paramedian Thalamic Stroke Infarction: A Comparative Study

The findings of this single case study suggest the possibility that the profile and severity of the executive dysfunction are determinant for the memory deficits and depend on from the side of the lesion.

Associative Learning Beyond the Medial Temporal Lobe: Many Actors on the Memory Stage

Investigating the functional architecture of the medial temporal lobe with respect to recognition memory and recall concludes that integrity of the thalamo-frontal and the th alamo-retrosplenial networks is necessary for the manifold features of episodic memory.

Neuropsychological outcome following thalamic stroke in adolescence: an identical twin comparison

These results suggest risk for deficits in encoding of new verbal information following bilateral thalamic stroke in adolescence, as well as risk for persistent cognitive deficits despite initial improvements, consistent with descriptions of anterograde memory impairments in adults with similar lesions.

A role for anterior thalamic nuclei in affective cognition: Interaction with environmental conditions

The results show that the ATN regulate affective cognition and that damage to this region may produce markedly different behavioral effects as a function of environmental housing conditions.

Injury of the Mammillothalamic Tract in Patients with Thalamic Hemorrhage

It is found that a large portion of patients with thalamic hemorrhage appeared to suffer severe injury of the ipsilesional MTT and 18.2% of them appeared to suffering severe injury even in the contralesional M TT.



A case of bilateral thalamic lesions with anterograde amnesia and impaired implicit memory.

The case of a woman with discrete thalamic lesions involving the anterior and dorsomedial nuclei who had a persistent anterograde amnesia is reported.

Memory in a case of bilateral thalamic infarction

It is suggested that the memory deficit results from a disconnection of the diencephalon from the medial temporal region.

Persistent global amnesia following right thalamic stroke: an 11-year longitudinal study.

Evidence suggests that a lesion confined to the thalamus may not on its own account for severe amnesia; that involvement of other structures is necessary for severeAmnesia to appear; and that a functional investigation should always be included in cases of small thalamic lesions before drawing conclusions about the structures responsible for a given deficit.

Autobiographical amnesia resulting from bilateral paramedian thalamic infarction A case study in cognitive neurobiology

SUMMARY A patient with a chronic amnesic state resulting from bilateral paramedian thalamic infarction showed a pattern of retrograde amnesia not previously reported. Personally relevant

Preserved memory traces within diencephalic amnesia

The present study indicated that the bilateral thalamic lesions of the patient disconnected the information processing stream between the primed information and the behavioural response, indicating preservation of this robust form of memory.

Neuropsychology of infarctions in the thalamus: a review

Neuropsychological correlates of a right unilateral lacunar thalamic infarction

The data indicate that the cognitive profile is the result of a dysfunction of executive functions, thought to be caused by disconnection of the prefrontal cortex from the brainstem activating nuclei through the strategic localisation of the right thalamic infarction.