Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region.

@article{Takemoto1998Th2specificDI,
  title={Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region.},
  author={Naofumi Takemoto and Naoko Koyano-Nakagawa and Takashi Yokota and Naoko Arai and Shoichiro Miyatake and Ken-ichi Arai},
  journal={International immunology},
  year={1998},
  volume={10 12},
  pages={1981-5}
}
IL-4 and IL-13 are cytokines preferentially produced by Th2 cells, and their genes are located in close proximity on human chromosome 5 and mouse chromosome 11. To identify potential regulatory elements that confer Th2-specific expression of IL-4 and IL-13 genes, we constructed a physical map of the IL-13/IL-4 locus and conducted DNase I-hypersensitive (DH) site analysis using Th clones and in vitro-differentiated effector Th cells obtained from TCR transgenic mice. Three DH sites, HSS1, HSS2… CONTINUE READING

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