Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4.

@article{Herrick2000Th2RI,
  title={Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4.},
  author={Christina A. Herrick and Heather Macleod and Earl J Glusac and Robert E. Tigelaar and Kim Bottomly},
  journal={The Journal of clinical investigation},
  year={2000},
  volume={105 6},
  pages={765-75}
}
Atopic individuals are predisposed to mounting vigorous Th2-type immune responses to environmental allergens. To determine the factors responsible, animal models that closely mimic natural modes of allergen exposure should prove most informative. Therefore, we investigated the role of IL-4, a known Th2-promoting cytokine, in generation of Th2 responses after exposure of either the skin or airway to soluble protein. Compared with wild-type (WT) mice, IL-4-deficient (IL-4(-/-)) mice showed… CONTINUE READING

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