Th2 polarization by Der p 1--pulsed monocyte-derived dendritic cells is due to the allergic status of the donors.

@article{Hammad2001Th2PB,
  title={Th2 polarization by Der p 1--pulsed monocyte-derived dendritic cells is due to the allergic status of the donors.},
  author={Hamida Hammad and A S Charbonnier and Catherine Duez and Alexandra Jacquet and Geoffrey A. Stewart and A. B. Tonnel and Joel Pestel},
  journal={Blood},
  year={2001},
  volume={98 4},
  pages={
          1135-41
        }
}
The polarization of the immune response toward a Th2 or a Th1 profile can be mediated by dendritic cells (DCs) following antigen presentation and interaction with T cells. Costimulatory molecules such as CD80 and CD86 expressed by DCs, the polarizing cytokine environment during DC--T-cell interaction, and also the nature of the antigen are critical in the orientation of the immune response. In this study, the effect of the cysteine protease Der p 1, one of the major allergens of the house dust… CONTINUE READING
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