Th2-like response and antitumor effect of anti-interleukin-4 mAb in mice bearing renal cell carcinoma

Abstract

 Tumor regression in experimental systems has been linked to the activities of Th1 cells. It is, therefore, conceivable that Th2 cells interrupt the expression of tumor immunity since interleukin-4 (IL-4) and IL-10 inhibit the generation of Th1 from precursors and modulate the competence of antigen-presenting cells to activate this lymphocyte subpopulation… (More)
DOI: 10.1007/s002620050347

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