Th2 cytokines increase Staphylococcus aureus alpha toxin induced keratinocyte death through the signal transducer and activator of transcription 6 (STAT6)

@inproceedings{Brauweiler2014Th2CI,
  title={Th2 cytokines increase Staphylococcus aureus alpha toxin induced keratinocyte death through the signal transducer and activator of transcription 6 (STAT6)},
  author={Anne M. Brauweiler and Elena Goleva and Donald Y. M. Leung},
  booktitle={The Journal of investigative dermatology},
  year={2014}
}
Atopic dermatitis (AD) is an inflammatory skin disease characterized by increased T-helper type 2 (Th2) cytokine expression. AD skin lesions are often exacerbated by Staphylococcus aureus-mediated secretion of the lytic virulence factor, alpha toxin. In the current study, we report that alpha toxin-induced cell death is greater in the skin from patients with AD compared with controls. Furthermore, we find that keratinocyte differentiation and Th2 cytokine exposure influence sensitivity to S… CONTINUE READING