Th2 cytokines in the asthma late-phase response

  title={Th2 cytokines in the asthma late-phase response},
  author={Patrick G. Holt and Peter D. Sly},
  journal={The Lancet},

A Review of the Pharmacological Properties of Psoralen

The antibacterial, anti-inflammatory and neuroprotective effects of psoralen are a result of its interaction with viral polymerase (Pol), destroying the formation of biofilm, and regulating the activation of tumor necrosis factor alpha (TNF-α), transforming growth factor beta (TGF-β) and the hypothalamic-pituitary-adrenal (HPA) axis.

Role of iBALT in Respiratory Immunity.

The activity of iBALT is demonstrably beneficial for the clearance of respiratory pathogens; however, it is less clear whether it dampens or exacerbates inflammatory responses to non-infectious agents.

IL‐37 attenuates allergic process via STAT6/STAT3 pathways in murine allergic rhinitis

Berberine improves airway inflammation and inhibits NF-κB signaling pathway in an ovalbumin-induced rat model of asthma

Berberine dose-dependently reversed the alterations induced by OVA in the asthmatic rats and suggested a therapeutic potential of berberine on OVA- induced airway inflammation.

TH9 cell differentiation, transcriptional control and function in inflammation, autoimmune diseases and cancer

It is now clear that TH9 cells play critical roles in immune-mediated diseases, including allergic airway, autoimmune and inflammatory bowel diseases, and cancer, and the promotion or suppression of TH9 cell differentiation, transcriptional control and function may provide novel treatments for clinical inflammation, autoimmune diseases and tumors.

Sesamin attenuates allergic airway inflammation through the suppression of nuclear factor-kappa B activation.

It is demonstrated that sesamin decreases the activation of NF-κB in order to attenuate allergic airway inflammation in a murine model of asthma, possibly via the regulation of phosphorylation of p38 MAPK.

Diagnostic Value of Serum Baseline Tryptase Levels in Childhood Asthma and Its Correlation with Disease Severity

Whether serum baseline tryptase (sBT) levels might be a useful marker not only for the accurate diagnosis of childhood asthma, but also for the prediction of disease severity is explored.

Ginsenoside Rh2 attenuates allergic airway inflammation by modulating nuclear factor-κB activation in a murine model of asthma.

The results suggested that G-Rh2 attenuates allergic airway inflammation by regulating NF-κB activation and p38 MAPK phosphorylation induced by OVA inhalation, which supported the potential use of G- Rh2 to prevent and/or treat asthma and other airway inflammatory disorders.

The polymeric mucin Muc5ac is required for allergic airway hyperreactivity

It is shown that formation of airway plugs by mucus promotes airway hypersensitivity, while deletion of mucous component Muc5acablates it independently of inflammation, which may be effective for treating asthma and other lung diseases where it is also overproduced.



The inflammation–repair cycle in asthma: the pivotal role of the airway epithelium

  • Holgate
  • Biology, Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 1998
The last decade has witnessed a considerable increase in knowledge of the factors underlying airway dysfunction in asthma, and the clear association of airway inflammation with all forms of the disease is of special importance.

The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis.

It is demonstrated that upper respiratory viral infections are strongly associated in time with hospital admissions for asthma in children and adults and school attendance was found to be a major confounding variable in children.

Late asthmatic reactions induced by inhalation of allergen-derived T cell peptides.

It is shown that inhalation of Fel d 1-derived peptides induced isolated LAR in individuals with asthma sensitive to cat allergen comparable with that previously demonstrated using intradermal injection and represents a novel model of provoked asthma.

Reassessing the Th2 cytokine basis of asthma.

Drug development strategies for asthma: in search of a new paradigm

It is argued that the continuation of this trend is inevitable unless there is a substantial realignment of entrenched drug development policy in the pharmaceutical industry and a parallel shift in licensing policy by regulatory authorities to encourage the development of drugs capable of halting the progression of asthma when the disease first manifests in childhood.

Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data

Recent data on human mast cells is summarized, differences with murine mast cells are discussed, and new tools to study this increasingly meaningful cell type in humans are described.

Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children

Natural virus infection and real life allergen exposure in allergic asthmatic children increase the risk of hospital admission.