Th2 cytokines impair innate immune responses to rhinovirus in respiratory epithelial cells.

  title={Th2 cytokines impair innate immune responses to rhinovirus in respiratory epithelial cells.},
  author={Marco Contoli and Kazuhiro Ito and Anna Padovani and Donatella Poletti and Brunilda Marku and Michael J. Edwards and Luminita A. Stanciu and Giulia Gnesini and Antonio Luigi Pastore and Antonio Spanevello and Paolo Morelli and S. L. Johnston and Gaetano Caramori and Alberto Papi},
  volume={70 8},
BACKGROUND Asthma and other Th2 inflammatory conditions have been associated with increased susceptibility to viral infections. The mechanisms by which Th2 cytokines can influence immune responses to infections are largely unknown. METHODS We measured the effects of Th2 cytokines (IL-4 and IL-13) on bronchial epithelial cell innate immune antiviral responses by assessing interferon (IFN-β and IFN-λ1) induction following rhinovirus (RV)-16 infection. We also investigated the modulatory effects… CONTINUE READING
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