Th2 cytokines exert a dominant influence on epithelial cell expression of the major group human rhinovirus receptor, ICAM-1.

@article{Bianco1998Th2CE,
  title={Th2 cytokines exert a dominant influence on epithelial cell expression of the major group human rhinovirus receptor, ICAM-1.},
  author={Assunta Dal Bianco and Sunil K Sethi and Jeremy T. Allen and Richard A Knight and Monica A. Spiteri},
  journal={The European respiratory journal},
  year={1998},
  volume={12 3},
  pages={619-26}
}
Intercellular adhesion molecule (ICAM)-1 is a cell receptor important in both human rhinovirus (HRV) attachment and immune effector cell mobilization. The level of expression of ICAM-1 by epithelial cells (EC) therefore plays a crucial role in the intricate biological phenomena underlying viral binding, host infection and consequent inflammatory events. As T-helper (Th)2 lymphocytes predominate within the asthmatic airway, the influence was evaluated of Th2-associated mediators in the… CONTINUE READING