Th2 cells mediate IL-4-dependent local tissue inflammation.

  title={Th2 cells mediate IL-4-dependent local tissue inflammation.},
  author={Kai M. M{\"u}ller and Fabienne Jaunin and Isabelle Masouy{\'e} and Jean Hilaire Saurat and Conrad Hauser},
  journal={Journal of immunology},
  volume={150 12},
We investigated whether polyclonal murine Th1 and Th2 cells obtained after short term culture in vitro were capable of mediating tissue inflammation in vivo. Th cells were pulsed with mAb to the TCR/CD3 complex and injected into the footpads or ears of naive syngeneic recipient mice. Th1 induced delayed swelling that peaked at 24 to 48 h and lasted > or = 5 days. Th2-induced swelling peaked at 6 h and lasted < or = 48 h. Similar responses were also observed in athymic nude mice. Lesions with… CONTINUE READING
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