Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB.

@article{Hartenstein2002Th2CC,
  title={Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB.},
  author={Bettina Hartenstein and Sibylle Teurich and Jochen Hess and Johannes Schenkel and Marina Schorpp-Kistner and Peter Angel},
  journal={The EMBO journal},
  year={2002},
  volume={21 23},
  pages={
          6321-9
        }
}
Naïve CD4+ T cells differentiate into effector T helper 1 (Th1) or Th2 cells, which are classified by their specific set of cytokines. Here we demonstrate that loss of JunB in in vitro polarized Th2 cells led to a dysregulated expression of the Th2-specific cytokines IL-4 and IL-5. These cells produce IFN-gamma and express T-bet, the key regulator of Th1 cells. In line with the essential role of Th2 cells in the pathogenesis of allergic asthma, mice with JunB-deficient CD4+ T cells exhibited an… CONTINUE READING
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