Th17 cytokines interleukin (IL)‐17 and IL‐22 modulate distinct inflammatory and keratinocyte‐response pathways

@article{Nograles2008Th17CI,
  title={Th17 cytokines interleukin (IL)‐17 and IL‐22 modulate distinct inflammatory and keratinocyte‐response pathways},
  author={K E Nograles and Lisa C. Zaba and Emma Guttman-Yassky and Judilyn Fuentes-Duculan and Mayte Su{\'a}rez-Fari{\~n}as and Irma R Cardinale and Artemis Khatcherian and J Gonzalez and Katherine C. Pierson and Traci R White and Cara A Pensabene and Israel Coats and I. K. Novitskaya and Michelle A. Lowes and James G. Krueger},
  journal={British Journal of Dermatology},
  year={2008},
  volume={159}
}
Background  Psoriasis vulgaris is an inflammatory skin disease mediated by Th1 and Th17 cytokines, yet the relative contribution of interferon (IFN)‐γ, interleukin (IL)‐17 and IL‐22 on disease pathogenesis is still unknown. 
Expression of interleukin (IL)‐1 family members upon stimulation with IL‐17 differs in keratinocytes derived from patients with psoriasis and healthy donors
Background A number of studies have challenged the T‐cell‐centred pathogenetic view of psoriasis by the finding that epithelium‐expressed genes are intimately involved in the inflammatory process.Expand
Etanercept suppresses regenerative hyperplasia in psoriasis by acutely downregulating epidermal expression of interleukin (IL)‐19, IL‐20 and IL‐24
Background Psoriasis is a Th17/Th1‐mediated skin disease that often responds to antitumour necrosis factor (TNF)‐α therapies, such as etanercept.
IL-23/T H 17 Pathway in Psoriasis and Inflammatory Skin Diseases
TLDR
The contributions of TH17 cells in psoriasis, as well as in other inflammatory skin diseases, are discussed in this chapter. Expand
The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses.
TLDR
The discovery of these genetic mutations in familial and pustular psoriasis suggests new links between cytokine-induced gene products and IL-1 family members from keratinocytes, which may regulate features of the disease, including epidermal hyperplasia and neutrophil infiltrating responses. Expand
Interleukin‐17A: a unique pathway in immune‐mediated diseases: psoriasis, psoriatic arthritis and rheumatoid arthritis
TLDR
Experimental evidence points to the importance of the cytokine interleukin‐17A in the pathogenesis of several immunoinflammatory diseases including psoriasis, psoriatic arthritis and rheumatoid arthritis, although levels of response are not predicted by pre‐clinical findings. Expand
T‐helper 22 cells as a new player in chronic inflammatory skin disorders
TLDR
The role of Th22 and its cytokine IL‐22 in the immunopathogenesis of inflammatory skin disorders such as psoriasis and atopic dermatitis is discussed. Expand
Psoriasis: rationale for targeting interleukin‐17
TLDR
IL‐17A is an attractive therapeutic target, which may allow selective intervention to address the dysregulated immune system in plaque psoriasis, and three agents markedly reduced disease severity in patients with moderate‐to‐severe plaque Psoriasis. Expand
Interleukin-17A and Keratinocytes in Psoriasis
TLDR
This review focuses on IL-17A and keratinocyte interaction regarding psoriasis pathogenesis, which results in characteristic histopathological features, such as epidermal hyperproliferation, intraepidermal neutrophilic microabscess, and dermal CCR6+ cell infiltration. Expand
Critical role of the interleukin‐23//T‐helper 17 cell axis in the pathogenesis of psoriasis
  • K. Nakajima
  • Biology, Medicine
  • The Journal of dermatology
  • 2012
TLDR
This model mouse for psoriasis not only verifies the therapeutic efficacies of biologics that specifically target the IL‐23//Th17 axis, but also clarifies the pathogenesis of psorosis. Expand
Increased gene expression of Toll‐like receptor 4 on peripheral blood mononuclear cells in patients with psoriasis
Background  A role for the innate immune system in driving the autoimmune T cell cascade in psoriasis has been proposed. Toll‐like receptors‐(TLR)‐2 and ‐4 play a role in inflammation,Expand
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The results suggest that TH17 cells, through the production of both IL-22 and IL-17, might have essential functions in host defence and in the pathogenesis of autoimmune diseases such as psoriasis. Expand
IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation.
TLDR
It is proposed that IL-22 antagonism might be a promising therapy for the treatment of human psoriasis, which is induced by the transfer of CD4(+)CD45RB(hi)CD25(-) cells to pathogen-free scid/scid mice. Expand
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Evidence is presented that murine IL-23, which is produced by activated dendritic cells, acts on memory T cells, resulting in elevated IL-17 secretion, which suggests that during a secondary immune response, IL- 23 can promote an activation state with features distinct from the well characterized Th1 and Th2 profiles. Expand
A role for T cell‐derived interleukin 22 in psoriatic skin inflammation
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The results reported in this study indicate that IL‐22 is a cytokine produced by skin‐infiltrating lymphocytes that is potentially involved in initiation and/or maintenance of the pathogenesis of psoriasis. Expand
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Treatment with anti-IL-23p19 effectively inhibited multiple inflammatory pathways that are critical for driving CNS autoimmune inflammation and prevented subsequent disease relapse. Expand
Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses
TLDR
It is shown that etanercept has early inhibitory effects on a newly appreciated type of T cells: T helper type 17 (Th17) cells, which may be particularly important in driving epidermal activation in psoriatic plaques whereas Th1 cells must also be eliminated for final disease resolution. Expand
The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in Psoriasis
TLDR
It is shown that primary human keratinocytes express receptors for these cytokines and that IL-20 subfamily cytokines induce acanthosis in reconstituted human epidermis (RHE) in a dose-dependent manner. Expand
Development, cytokine profile and function of human interleukin 17–producing helper T cells
TLDR
It is demonstrated that IL-23 and IL-1β induced the development of human and mouse TH-17 cells expressing IL-17A,IL-17F, IL-22, Il-26, interferon-γ, the chemokine CCL20 and transcription factor RORγt, and that human TH- 17 cells may regulate innate immunity in epithelial cells. Expand
Role of neutrophils in induction of acute inflammation in T‐cell‐mediated immune dermatosis, psoriasis: A neutrophil‐associated inflammation‐boosting loop
TLDR
A neutrophil‐associated inflammation‐boosting loop is proposed that may well explain the localized “acute” inflammatory changes scattered over the ‘’chronic” psoriatic plaques as well as in the acutely inflamed lesions of pustular psoriasis. Expand
IL‐22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis
TLDR
It is demonstrated that IL‐22, in contrast to its relative IFN‐γ, regulates the expression of only a few genes in keratinocytes, which may be important in the innate immunity and reorganization of epithelia. Expand
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