Th17 cytokines and their emerging roles in inflammation and autoimmunity.

  title={Th17 cytokines and their emerging roles in inflammation and autoimmunity.},
  author={Lynette A. Fouser and Jill F. Wright and Kyriaki Dunussi-Joannopoulos and Mary I. Collins},
  journal={Immunological reviews},
T-helper 17 (Th17) cells are a new lineage of CD4(+) T cells that are characterized by their production of interleukin-17A (IL-17A). Recent studies show that these cells can also express IL-17F, IL-22, and IL-21. IL-17A and IL-17F can form a heterodimeric cytokine, which mediates biological activities, at least in part, through shared receptors with IL-17A and IL-17F homodimers. The cytokines made by Th17 cells represent three distinct gene families, highlighting the unique biology of these… CONTINUE READING

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