Th17 cells promote autoimmune anti-myeloperoxidase glomerulonephritis.

  title={Th17 cells promote autoimmune anti-myeloperoxidase glomerulonephritis.},
  author={Poh-Yi Gan and Oliver M Steinmetz and Diana S Y Tan and Kim Maree O'Sullivan and Joshua Daniel Ooi and Yoichiro Iwakura and Arthur Richard Kitching and Stephen Roger Holdsworth},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={21 6},
A major target autoantigen in anti-neutrophil cytoplasmic antibody-associated vasculitis is myeloperoxidase (MPO). Although MPO-specific CD4+ Th cells seem to orchestrate renal injury, the role of the Th17 subset is unknown. We hypothesized that Th17 cells direct injurious anti-MPO autoimmunity in experimental murine anti-MPO-induced glomerulonephritis (GN). We immunized mice with MPO to establish autoimmunity, resulting in systemic IL-17A production with MPO-specific dermal delayed-type… CONTINUE READING
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