Th17 cells in inflammation and autoimmunity.

  title={Th17 cells in inflammation and autoimmunity.},
  author={Ram Pyare Singh and Sascha Hasan and Sherven P Sharma and Saranpreet Nagra and Dean T. Yamaguchi and David Wong and Bevra Hannahs Hahn and Awlad Hossain},
  journal={Autoimmunity reviews},
  volume={13 12},
T helper 17 (Th17), a distinct subset of CD4(+) T cells with IL-17 as their major cytokine, orchestrate the pathogenesis of inflammatory and autoimmune diseases. Dysregulated Th17 cells contribute to inflammatory and autoimmune diseases. Candidate biologics are in development for targeting IL-17, IL-17 receptors or IL-17 pathways. Several drugs that impact the IL-17 pathway are already in clinical trials for the treatment of autoimmune diseases. In this review we provide evidence for the role… CONTINUE READING
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Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype

  • S. Ghannam, J. Pene, G. Torcy-Moquet, C. Jorgensen, H. Yssel
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  • 2010
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