Th17 cells favor inflammatory responses while inhibiting type I collagen deposition by dermal fibroblasts: differential effects in healthy and systemic sclerosis fibroblasts

@inproceedings{Brembilla2013Th17CF,
  title={Th17 cells favor inflammatory responses while inhibiting type I collagen deposition by dermal fibroblasts: differential effects in healthy and systemic sclerosis fibroblasts},
  author={Nicol{\`o} Costantino Brembilla and Elisa Montanari and M E Truchetet and Elena Raschi and Pier Luigi Meroni and Carlo Chizzolini},
  booktitle={Arthritis research & therapy},
  year={2013}
}
INTRODUCTION T helper (Th)-17 cells are increased in systemic sclerosis (SSc). We therefore assessed whether Th17 cells could modulate the inflammatory and fibrotic responses in dermal fibroblasts from healthy donors (HD) and SSc individuals. METHODS Fibroblasts were obtained from 14 SSc and 8 HD skin biopsies. Th17 clones were generated from healthy peripheral blood upon enrichment of CC chemokine receptor (CCR)-4/CCR6/CD161 expressing cells. Their cytokine production was assessed by flow… CONTINUE READING
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