Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner.

@article{Huber2011Th17CE,
  title={Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner.},
  author={Samuel Huber and Nicola Gagliani and Enric Esplugues and William K O'Connor and Francis Jessica Huber and Ashutosh Chaudhry and Masahito Kamanaka and Yasushi Kobayashi and Carmen J Booth and Alexander Y Rudensky and Maria Grazia Roncarolo and Manuela Battaglia and Richard A Flavell},
  journal={Immunity},
  year={2011},
  volume={34 4},
  pages={554-65}
}
T helper 17 (Th17) cells are important for host defense against extracellular microorganisms. However, they are also implicated in autoimmune and chronic inflammatory diseases, and as such need to be tightly regulated. The mechanisms that directly control committed pathogenic Th17 cells in vivo remain unclear. We showed here that IL-17A-producing CD4+ T… CONTINUE READING