Th17 cells and IL-17 promote the skin and lung inflammation and fibrosis process in a bleomycin-induced murine model of systemic sclerosis.

@article{Lei2016Th17CA,
  title={Th17 cells and IL-17 promote the skin and lung inflammation and fibrosis process in a bleomycin-induced murine model of systemic sclerosis.},
  author={Ling Lei and Cheng Zhao and Fang Qin and Zhiyi He and Xu Wang and Xiao-ning Zhong},
  journal={Clinical and experimental rheumatology},
  year={2016},
  volume={34 Suppl 100 5},
  pages={14-22}
}
OBJECTIVES Systemic sclerosis (SSc) is characterised by fibrosis of the skin and internal organs, such as the lungs. Enhanced Th17 responses are associated with skin fibrosis in patients with SSc, however, whether they are associated with lung fibrosis has not been clarified. This study aimed to investigate the potential association of Th17 responses with the skin and pulmonary fibrosis as well as the potential mechanisms in a mouse bleomycin (BLM) model of SSc. METHODS BALB/c mice were… CONTINUE READING

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