Th17 cells: from precursors to players in inflammation and infection.

@article{Awasthi2009Th17CF,
  title={Th17 cells: from precursors to players in inflammation and infection.},
  author={Amit Awasthi and Vijay K Kuchroo},
  journal={International immunology},
  year={2009},
  volume={21 5},
  pages={489-98}
}
Upon activation, naive CD4(+) T cells differentiate into different lineages of effector T(h) subsets. Each subset is characterized by its unique cytokine profile and biological functions. T(h)17, a newly described T(h) subset that produces IL-17, IL-17F and IL-22 in preference to other cytokines, has been shown to play an important role in clearing specific pathogens and in inducing autoimmune tissue inflammations. Over the last 2-3 years, significant progress has been made to understand the… CONTINUE READING
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IL - 21 and TGF - beta are required for differentiation of human T ( H ) 17 cells

L. Yang, D. E. Anderson, C. Baecher-Allan
Nature • 2008

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